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Title Advances in Combinatorial Chemistry High Throughput Screening
Author Rathnam Chaguturu
Publisher Bentham Science Publishers
Release Date 2013-08-06
Category Science
Total Pages 265
ISBN 9781608057450
Language English, Spanish, and French
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Book Summary:

Advances in Combinatorial Chemistry & High Throughput Screening, is an e-book series comprising updated research articles previously published in the impact factor journal, Combinatorial Chemistry & High Throughput Screening (CCHTS). A wide range of topics are covered by these articles including chemical biology, high throughput screening, combinatorial chemistry, chemoinformatics, laboratory automation and compound management. This series is, therefore, a testament to CCHTS contributions in advancing drug discovery on full throttle. This eBook series opens up a new avenue for rapid access for readers – including academic researchers and industry professionals - to a focused collection of highly regarded contributions in the field.

Title Advances in Drug Discovery Techniques
Author Alan L. Harvey
Publisher CRC Press
Release Date 1998-08-15
Category Medical
Total Pages 222
ISBN 0471975095
Language English, Spanish, and French
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Book Summary:

A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.

Title Comprehensive Medicinal Chemistry II
Author David J Triggle
Publisher Elsevier
Release Date 2006-12-29
Category Medical
Total Pages 7200
ISBN 9780080445137
Language English, Spanish, and French
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Book Summary:

The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Title A Practical Guide to Assay Development and High Throughput Screening in Drug Discovery
Author Taosheng Chen
Publisher CRC Press
Release Date 2009-12-21
Category Medical
Total Pages 291
ISBN 9781420070514
Language English, Spanish, and French
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Book Summary:

The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P

Combinatorial Library by Lisa Bellavance English

Title Combinatorial Library
Author Lisa Bellavance English
Publisher Springer Science & Business Media
Release Date 2002
Category Medical
Total Pages 396
ISBN 9781592592852
Language English, Spanish, and French
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Book Summary:

By significantly increasing the number of targets available for drug discovery, the Human Genome and Proteome projects have made the use of combinatorial libraries essential to developing and optimizing drug candidate molecules more rapidly. Lisa English and a panel of expert researchers have collected in Combinatorial Library Methods and Protocols a novel series of computational and laboratory methods for the design, synthesis, quality control, screening, and purification of combinatorial libraries. Here the reader will find cutting-edge techniques for the preparation of encoded combinatorial libraries, for the synthesis of DNA-binding polyamides, and for combinatorial receptors. There are also state-of-the-art methods for computational library design, quality control by mass spectrometry, and structure verification using 1D and 2D NMR. A variety of well-known computational approaches are provided to meet the information management challenge of multiple biological assays. Each readily reproducible technique includes detailed step-by-step instructions and helpful notes on troubleshooting and avoiding pitfalls. Timely and highly practical, Combinatorial Library Methods and Protocols makes available for all drug discovery researchers all the powerful combinatorial chemistry tools that are increasing the number of candidate compounds and speeding the process of drug discovery and development today.

Title High Throughput Screening for Novel Anti Inflammatories
Author Michael Kahn
Publisher Springer Science & Business Media
Release Date 2000-05-01
Category Science
Total Pages 258
ISBN 3764359129
Language English, Spanish, and French
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Book Summary:

Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent the state of the art regarding the integration of combinatorial chemistry and HTS in connection with anti-inflammatory targets. Obviously, there is much work to be done beyond what is described in this text, nevertheless, it should set the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating inflammatory diseases.

Title High Throughput Screening in Drug Discovery
Author Jörg Hüser
Publisher John Wiley & Sons
Release Date 2006-12-13
Category Science
Total Pages 362
ISBN 9783527609369
Language English, Spanish, and French
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Book Summary:

Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.

Title Neurobiology of Huntington s Disease
Author Donald C. Lo
Publisher CRC Press
Release Date 2010-07-02
Category Science
Total Pages 338
ISBN 9781420008258
Language English, Spanish, and French
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Book Summary:

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Small Molecule Drug Discovery by Andrea Trabocchi

Title Small Molecule Drug Discovery
Author Andrea Trabocchi
Publisher Elsevier
Release Date 2019-11-23
Category Science
Total Pages 356
ISBN 9780128183502
Language English, Spanish, and French
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Book Summary:

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules

Title 3D Cell Based Biosensors in Drug Discovery Programs
Author William S. Kisaalita
Publisher CRC Press
Release Date 2010-06-22
Category Medical
Total Pages 404
ISBN 9781420073508
Language English, Spanish, and French
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Book Summary:

Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Bio

Title Combinatorial Methods for Chemical and Biological Sensors
Author Radislav A. Potyrailo
Publisher Springer Science & Business Media
Release Date 2009-03-21
Category Science
Total Pages 494
ISBN 0387737138
Language English, Spanish, and French
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Book Summary:

Chemical sensors are in high demand for applications as varied as water pollution detection, medical diagnostics, and battlefield air analysis. Designing the next generation of sensors requires an interdisciplinary approach. The book provides a critical analysis of new opportunities in sensor materials research that have been opened up with the use of combinatorial and high-throughput technologies, with emphasis on experimental techniques. For a view of component selection with a more computational perspective, readers may refer to the complementary volume of Integrated Analytical Systems edited by M. Ryan et al., entitled “Computational Methods for Sensor Material Selection”.

Title Structure based Drug Discovery
Author Harren Jhoti
Publisher Springer Science & Business Media
Release Date 2007-05-24
Category Science
Total Pages 250
ISBN 9781402044076
Language English, Spanish, and French
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Book Summary:

This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.

Title Carbohydrate Bioengineering
Author Tuula T Teeri
Publisher Royal Society of Chemistry
Release Date 2007-10-31
Category Science
Total Pages 206
ISBN 9781847550323
Language English, Spanish, and French
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Book Summary:

Carbohydrate bioengineering is a rapidly expanding field with many applications in medicine and industry. Presenting state-of-the-art research, Carbohydrate Bioengineering: Interdisciplinary Approaches brings together international experts on many different aspects of this burgeoning topic. Coverage includes: the engineering of glycosidases for constructive purposes; structure-function studies and protein engineering of carbohydrate-active enzymes; chemo-enzymatic carbohydrate synthesis; and trends emerging from comprehensive work on genomes and glycomes. This timely publication will be welcomed by all those needing access to the latest research in the field, including practitioners in the medicinal, chemical, food and pharmaceutical areas.

Title The Organic Chemistry of Drug Design and Drug Action
Author Richard B. Silverman
Publisher Elsevier
Release Date 2012-12-02
Category Science
Total Pages 422
ISBN 9780080571232
Language English, Spanish, and French
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Book Summary:

This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications

Computational Phytochemistry by Satyajit Dey Sarker

Title Computational Phytochemistry
Author Satyajit Dey Sarker
Publisher Elsevier
Release Date 2018-05-02
Category Science
Total Pages 364
ISBN 9780128125465
Language English, Spanish, and French
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Book Summary:

Computational Phytochemistry explores how recent advances in computational techniques and methods have been embraced by phytochemical researchers to enhance many of their operations, thus refocusing and expanding the possibilities of phytochemical studies. By applying computational aids and mathematical models to extraction, isolation, structure determination and bioactivity testing, researchers can extract highly detailed information about phytochemicals and optimize working approaches. This book aims to support and encourage researchers currently working with, or looking to incorporate, computational methods into their phytochemical work. Topics in this book include computational methods for predicting medicinal properties, optimizing extraction, isolating plant secondary metabolites and building dereplicated phytochemical libraries. The role of high-throughput screening, spectral data for structural prediction, plant metabolomics and biosynthesis are all reviewed, before the application of computational aids for assessing bioactivities and virtual screening are discussed. Illustrated with detailed figures and supported by practical examples, this book is an indispensable guide for all those involved with the identification, extraction and application of active agents from natural products. Includes step-by-step protocols for various computational and mathematical approaches applied to phytochemical research Features clearly illustrated chapters contributed by highly reputed researchers Covers all key areas in phytochemical research, including virtual screening and metabolomics

Combinatorial Chemistry by Stephen R. Wilson

Title Combinatorial Chemistry
Author Stephen R. Wilson
Publisher John Wiley & Sons
Release Date 1997-03-28
Category Medical
Total Pages 288
ISBN 047112687X
Language English, Spanish, and French
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Book Summary:

The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

Title Combinatorial Materials Synthesis
Author Xiao-Dong Xiang
Publisher CRC Press
Release Date 2003-08-19
Category Science
Total Pages 496
ISBN 0824741196
Language English, Spanish, and French
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Book Summary:

Pioneered by the pharmaceutical industry and adapted for the purposes of materials science and engineering, the combinatorial method is now widely considered a watershed in the accelerated discovery, development, and optimization of new materials. Combinatorial Materials Synthesis reveals the gears behind combinatorial materials chemistry and thin-film technology, and discusses the prime techniques involved in synthesis and property determination for experimentation with a variety of materials. Funneling historic innovations into one source, the book explores core approaches to synthesis and rapid characterization techniques for work with combinatorial materials libraries.

Plant Chemical Biology by Dominique Audenaert

Title Plant Chemical Biology
Author Dominique Audenaert
Publisher John Wiley & Sons
Release Date 2013-11-05
Category Science
Total Pages 312
ISBN 9781118742747
Language English, Spanish, and French
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Book Summary:

Demonstrates how advances in plant chemical biology cantranslate to field applications With contributions from a team of leading researchers andpioneers in the field, this book explains how chemical biology isused as a tool to enhance our understanding of plant biology.Readers are introduced to a variety of chemical biology studiesthat have provided novel insights into plant physiology and plantcellular processes. Moreover, they will discover that chemicalbiology not only leads to a better understanding of the underlyingmechanisms of plant biology, but also the development of practicalapplications. For example, the authors discuss small molecules thatcan be used to identify targets of herbicides and develop newherbicides and plant growth regulators. The book begins with a historical perspective on plant chemicalbiology. Next, the authors introduce the chemical biology toolboxneeded to perform successful studies, with chapters covering: Sources of small molecules Identification of new chemical tools by high-throughputscreening (HTS) Use of chemical biology to study plant physiology Use of chemical biology to study plant cellular processes Target identification Translation of plant chemical biology from the lab to thefield Based on the latest findings and extensively referenced, thebook explores available compound collections, principles of assaydesign, and the use of new research tools for the development ofnew applications. Plant Chemical Biology is recommended for students andprofessionals in all facets of plant biology, including molecularbiology, physiology, biochemistry, agriculture, horticulture, andagronomy. All readers will discover new approaches that can lead tothe development of a healthier and more plentiful global foodsupply.

Title Fragment based Approaches in Drug Discovery
Author Wolfgang Jahnke
Publisher John Wiley & Sons
Release Date 2006-12-13
Category Science
Total Pages 391
ISBN 9783527608607
Language English, Spanish, and French
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Book Summary:

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.

Molecular Insight Of Drug Design by Arli Aditya Parikesit

Title Molecular Insight of Drug Design
Author Arli Aditya Parikesit
Publisher BoD – Books on Demand
Release Date 2018-08-29
Category Medical
Total Pages 130
ISBN 9781789236323
Language English, Spanish, and French
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Book Summary:

The approaches in drug design are mainly comprised of these three multidisciplinary sciences. First, Bioinformatics has successfully gather biological data in form of biomolecular sequences, in order to construct knowledge on drug and vaccine design. It is of considerable importance for drug designers to comprehend the utilization of bioinformatics tools for resolving their research questions. Second, Nanotechnology has made possible the design and delivery of the nano-based drug. Third, Pharmaceutical Chemistry made it possible to investigate the adsorption, distribution, metabolism, and toxicology of the drug candidates in a fine-grained resolution.